Episode 1 - Frontline, Part 1

Dr. Murphy treats a patient who has an illness that is not only unpredictable in nature, but also unlike anything he or the team has seen before. Dr. Claire Brown continues to work through her grief, still reeling from Dr. Neil Melendez's death.

Episode 2 - Frontline, Part 2

Shaun has a hard time balancing his fears and concerns about potentially jeopardizing Lea's health and wanting to be with the woman he loves. Claire looks for a way to grieve Melendez's death. Park and Mia discuss their future together.

Episode 3 - Newbies

With several candidates vying for residency at St. Bonaventure, Chief of Surgery Dr. Audrey Lim tasks Dr. Shaun Murphy, Dr. Claire Browne and Dr. Alex Park with mentoring the top first-year resident contenders. As their mentees shadow them for the day, Shaun and Park meet with Andrews to discuss a difficult surgery scheduled for a minor. Later, Shaun inadvertently insults Lea while discussing the pros and cons of the controversial surgery. And elsewhere, Dr. Morgan Reznick seeks out Claire and Lim’s help on a consult.

Episode 4 - Not the Same

Dr. Morgan Reznik and Dr. Shaun Murphy's pregnant patient with twins is having pain and they are forced to grapple with a decision no one wants to make. Meanwhile, Shaun asks Lea to move back in despite her reservations

Episode 5 - Fault

Dr. Shaun Murphy questions his decision to give the new residents autonomy when one of his intern's misdiagnosis of a patient has dire consequences. Meanwhile, Dr. Claire Browne, Dr. Alex Park and Dr. Jordan Allen treat a patient with a ruptured cyst affecting key functions of her brain. And elsewhere, Dr. Morgan Reznick and Park bond over failed relationships.

Episode 6 - Lim

As Chief of Surgery Dr. Audrey Lim struggles to cope with the residual emotional trauma of COVID-19, she encounters a young war veteran fighting debilitating PTSD. After discussing his case with the team, Dr. Claire Browne suggests a radical treatment to help him. Meanwhile, still reeling from the recent loss of his mentee’s patient, Dr. Shaun Murphy declares he doesn’t want to teach the new residents anymore. And elsewhere, an eccentric patient keeps the team entertained.

Episode 7 - The Uncertainty Principle

Dr. Morgan Reznik discovers her patient’s wealth and obsession with extending his life is a dangerous mix that could end up costing more than he can afford.

Episode 8 - Parenting

The team treats a teenage gymnast who experiences complications from her intensive training. Meanwhile, Shaun meets Lea's parents for the first time.

Episode 9 - Irresponsible Salad Bar Practices

Lim is challenged by the unique circumstances surrounding a pregnant patient with an aggressive tumor. Elsewhere, after misdiagnosing a patient, Claire makes a disconcerting discovery about certain practices at the hospital.

Episode 10 - Decrypt

When the hospital is hit with a cyberattack threatening to shut down life-saving machines, Lea rises to the challenge and looks to outsmart the hackers to prove herself. Meanwhile, the team treats an inspirational cancer survivor-turned-successful-philanthropist who harbors a dark secret.

Episode 11 - We're All Crazy Sometimes

After bringing in an incredibly unique and complicated spinal surgery, Dr. Aaron Glassman challenges the residents for an opportunity to join him in the operating room. Meanwhile, Shaun and Morgan disagree on how to treat a comatose patient with a cancerous tumor.

Episode 12 - Episode 12

Episode 13 - Episode 13